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ABSTRACT: Objective
To investigate the value of integrin ?v?3 targeted imaging with 99mTc-HYNIC-PEG4-E[PEG4-c(RGDfk)]2 (99mTc-3P-RGD2) as a radiotracer in dectecting osteolytic bone metastases.Methods
This is a retrospective study involving a cohort of 69 consecutive patients including 59 with lung cancer and 10 with other cancers. Patients were required to receive whole body scan (WBS) and regional SPECT/CT imaging with 99mTc-3P-RGD2 (RGD imaging) and 99mTc-MDP (MDP imaging) as a radiotracer successively within days. Final diagnosis was based on comprehensive assessment of all available data including case history, CT, MRI, SPECT/CT, PET/CT, histopathology and 6-12 months follow-up. Visual observation and semiquantitative analysis (T/N: tracer uptake ratio of osteolytic metastases to normal bone) of 99mTc-3P-RGD2 or 99mTc-MDP imaging were performed and their detective values for osteolytic metastases were compared.Results
A total of 131 osteolytic metastatic lesions were retrospectively studied. Osteolytic metastases mainly presented as "hot region", occasionally as "cool or normal region" on RGD imaging. The detection sensitivity of RGD WBS for osteolytic metastases was significantly higher than that of 99mTc-MDP WBS (80.9% vs. 46.6%, p<0.01). The sensitivity increased to 96.2% (126/131) when combining with SPECT/CT. 99mTc-3P-RGD2 imaging also promoted the detection of unknown primary tumor, lymph node metastases and offered information for clinical staging. T/N of 99mTc-3P-RGD2 in lung adenocarcinoma osteolytic metastases showed no statistical difference compared with that in squamous-cell carcinoma (6.84±3.46 vs. 7.33±3.22, t = 0.39, p = 0.71). Whereas, it was higher in osteolytic metastases from lung cancer than that from thyroid cancer (7.05±3.01 vs. 4.11±2.67, p = 0.03).Conclusion
99mTc-3P-RGD2 peptide imaging showed great potential for detection of osteolytic bone metastasis due to high expression level of integrin ?v?3 on osteoclast and most tumor cells.
SUBMITTER: Shao G
PROVIDER: S-EPMC5650448 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Shao Guoqiang G Gu Wei W Guo Muhong M Zang Shiming S Fu Jinjing J Liu Shuang S Wang Feng F Wang Zizheng Z
Oncotarget 20170427 43
<h4>Objective</h4>To investigate the value of integrin α<sub>v</sub>β<sub>3</sub> targeted imaging with <sup>99m</sup>Tc-HYNIC-PEG<sub>4</sub>-E[PEG<sub>4</sub>-c(RGDfk)]<sub>2</sub> (<sup>99m</sup>Tc-3P-RGD<sub>2</sub>) as a radiotracer in dectecting osteolytic bone metastases.<h4>Methods</h4>This is a retrospective study involving a cohort of 69 consecutive patients including 59 with lung cancer and 10 with other cancers. Patients were required to receive whole body scan (WBS) and regional SPE ...[more]