Genomic Insight into the Role of lncRNA in Cancer Susceptibility.
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ABSTRACT:
SUBMITTER: Gao P
PROVIDER: S-EPMC5486062 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Publications
Genomic Insight into the Role of lncRNA in Cancer Susceptibility.
International journal of molecular sciences 20170609 6
With the development of advanced genomic methods, a large amount of long non-coding RNAs (lncRNAs) has been found to be important for cancer initiation and progression. Given that most of the genome-wide association study (GWAS)-identified cancer risk SNPs are located in the noncoding region, the expression and function of lncRNAs are more likely to be affected by the SNPs. The SNPs may affect the expression of lncRNAs directly through disrupting the binding of transcription factors or indirectl ...[more]
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