Functional polymorphisms in LncRNA HOTAIR contribute to susceptibility of pancreatic cancer.

ABSTRACT:

Background

Pancreatic cancer (PC) remains one of the most aggressive cancers worldwide. However, genetic factors underlying PC susceptibility remain largely unclear. Long noncoding RNA (lncRNA) HOX transcript antisense RNA (HOTAIR) acts as an oncogene and its genetic variation has been linked to many cancers. However, the associations between genetic variants in HOTAIR gene and PC risk has not yet been reported.

Methods

A two-stage, case-control study was conducted to investigate the associations between HOTAIR SNPs and the PC risk. Dual luciferase reporter assay and real-time -PCR (RT-PCR) was conducted to evaluate the potential regulatory function of HOTAIR rs4759314 and rs200349340.

Results

We found the minor alleles of rs4759314 (OR = 1.76; 95 CI 1.37-2.25; P = 0.

SUBMITTER: Jiang D 

PROVIDER: S-EPMC6396528 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature