Ontology highlight
ABSTRACT:
SUBMITTER: Li J
PROVIDER: S-EPMC5486179 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Li Jieyao J Wang Liping L Chen Xinfeng X Li Lifeng L Li Yu Y Ping Yu Y Huang Lan L Yue Dongli D Zhang Zhen Z Wang Fei F Li Feng F Yang Li L Huang Jianmin J Yang Shuangning S Li Hong H Zhao Xuan X Dong Wenjie W Yan Yan Y Zhao Song S Huang Bo B Zhang Bin B Zhang Yi Y
Oncoimmunology 20170421 6
CD39/CD73-adenosine pathway has been recently defined as an important tumor-induced immunosuppressive mechanism. We here documented a fraction of CD11b<sup>+</sup>CD33<sup>+</sup> myeloid-derived suppressor cells (MDSCs) in peripheral blood and tumor tissues from non-small cell lung cancer (NSCLC) patients expressed surface ectonucleotidases CD39 and CD73. Tumor TGF-β stimulated CD39 and CD73 expression, thereby inhibited T cell and NK cell activity, and protected tumor cells from the cytotoxic ...[more]