Ontology highlight
ABSTRACT:
SUBMITTER: Ahmadi P
PROVIDER: S-EPMC7464076 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Ahmadi Parimah P Hartjen Philip P Kohsar Matin M Kummer Silke S Schmiedel Stefan S Bockmann Jan-Hendrik JH Fathi Anahita A Huber Samuel S Haag Friedrich F Schulze Zur Wiesch Julian J
Cells 20200722 8
The ectonucleotidases CD39 and CD73 regulate immune responses by balancing extracellular ATP and adenosine in inflammation and are likely to be involved in the pathophysiology of COVID-19. Here, we analyzed CD39 and CD73 on different lymphocyte populations in a small cohort of COVID-19 patients and in healthy individuals. We describe a significantly lower level of expression of CD73 on cytotoxic lymphocyte populations, including CD8<sup>+</sup> T, natural killer T (NKT), and natural killer (NK) ...[more]