Ontology highlight
ABSTRACT:
SUBMITTER: Ohnami S
PROVIDER: S-EPMC5487743 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Ohnami Shumpei S Ohshima Keiichi K Nagashima Takeshi T Urakami Kenichi K Shimoda Yuji Y Saito Junko J Naruoka Akane A Hatakeyama Keiichi K Mochizuki Tohru T Serizawa Masakuni M Ohnami Sumiko S Kusuhara Masatoshi M Yamaguchi Ken K
Molecular and cellular biochemistry 20170303 1-2
The TP53 signal transduction pathway is an attractive target for cancer treatments. In this study, we conducted a comprehensive molecular evaluation of 907 patients with cancer in Japan to identify genomic alterations in the TP53 pathway. TP53 mutations were frequently detected in many cancers, except melanoma, thymic tumors, gastrointestinal stromal tumors, and renal cancers. The frequencies of non-synonymous single nucleotide variants (SNVs) in the TP53 family members TP63 and TP73 were relati ...[more]