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Instantaneous Conversion of [11 C]CO2 to [11 C]CO via Fluoride-Activated Disilane Species.

ABSTRACT: The development of a fast and novel methodology to generate carbon-11 carbon monoxide ([11 C]CO) from cyclotron-produced carbon-11 carbon dioxide ([11 C]CO2 ) mediated by a fluoride-activated disilane species is described. This methodology allows up to 74?% conversion of [11 C]CO2 to [11 C]CO using commercially available reagents, readily available laboratory equipment and mild reaction conditions (room temperature). As proof of utility, radiochemically pure [carbonyl-11 C]N-benzylbenzamide was successfully synthesized from produced [11 C]CO in up to 74?% radiochemical yield (RCY) and >99?% radiochemical purity (RCP) in ?10?min from end of [11 C]CO2 delivery.

SUBMITTER: Taddei C 

PROVIDER: S-EPMC5488231 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature

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Instantaneous Conversion of [<sup>11</sup> C]CO<sub>2</sub> to [<sup>11</sup> C]CO via Fluoride-Activated Disilane Species.

Taddei Carlotta C   Bongarzone Salvatore S   Gee Antony D AD  

Chemistry (Weinheim an der Bergstrasse, Germany) 20170517 32

The development of a fast and novel methodology to generate carbon-11 carbon monoxide ([<sup>11</sup> C]CO) from cyclotron-produced carbon-11 carbon dioxide ([<sup>11</sup> C]CO<sub>2</sub> ) mediated by a fluoride-activated disilane species is described. This methodology allows up to 74 % conversion of [<sup>11</sup> C]CO<sub>2</sub> to [<sup>11</sup> C]CO using commercially available reagents, readily available laboratory equipment and mild reaction conditions (room temperature). As proof of u  ...[more]

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