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Carbon-11 carboxylation of trialkoxysilane and trimethylsilane derivatives using [11C]CO2.

ABSTRACT: A novel carboxylation radiosynthesis methodology is described starting from cyclotron-produced [11C]CO2 and fluoride-activated silane derivatives. Six carbon-11 labelled carboxylic acids were obtained from their corresponding trimethylsilyl and trialkoxysilyl precursors in a one-pot labelling methodology. The radiochemical yields ranged from 19% to 93% within 12 minutes post [11C]CO2 delivery with a trapping efficiency of 21-89%.

SUBMITTER: Bongarzone S

PROVIDER: S-EPMC7384297 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature

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Carbon-11 carboxylation of trialkoxysilane and trimethylsilane derivatives using [11C]CO2.

Bongarzone Salvatore S Raucci Nicola N Fontana Igor Camargo IC Luzi Federico F Gee Antony D AD

Chemical communications (Cambridge, England) 20200325 34

A novel carboxylation radiosynthesis methodology is described starting from cyclotron-produced [11C]CO2 and fluoride-activated silane derivatives. Six carbon-11 labelled carboxylic acids were obtained from their corresponding trimethylsilyl and trialkoxysilyl precursors in a one-pot labelling methodology. The radiochemical yields ranged from 19% to 93% within 12 minutes post [11C]CO2 delivery with a trapping efficiency of 21-89%. ...[more]

PMID: 32211652

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