Ontology highlight
ABSTRACT:
SUBMITTER: Wilson SS
PROVIDER: S-EPMC5489213 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Wilson Sarah S SS Bromme Beth A BA Holly Mayumi K MK Wiens Mayim E ME Gounder Anshu P AP Sul Youngmee Y Smith Jason G JG
PLoS pathogens 20170616 6
The small intestinal epithelium produces numerous antimicrobial peptides and proteins, including abundant enteric α-defensins. Although they most commonly function as potent antivirals in cell culture, enteric α-defensins have also been shown to enhance some viral infections in vitro. Efforts to determine the physiologic relevance of enhanced infection have been limited by the absence of a suitable cell culture system. To address this issue, here we use primary stem cell-derived small intestinal ...[more]