Ontology highlight
ABSTRACT:
SUBMITTER: Xu D
PROVIDER: S-EPMC6051418 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Xu Dan D Liao Chongbing C Zhang Bing B Tolbert W David WD He Wangxiao W Dai Zhijun Z Zhang Wei W Yuan Weirong W Pazgier Marzena M Liu Jiankang J Yu Jun J Sansonetti Philippe J PJ Bevins Charles L CL Shao Yongping Y Lu Wuyuan W
Immunity 20180529 6
Shigella is a Gram-negative bacterium that causes bacillary dysentery worldwide. It invades the intestinal epithelium to elicit intense inflammation and tissue damage, yet the underlying mechanisms of its host selectivity and low infectious inoculum remain perplexing. Here, we report that Shigella co-opts human α-defensin 5 (HD5), a host defense peptide important for intestinal homeostasis and innate immunity, to enhance its adhesion to and invasion of mucosal tissues. HD5 promoted Shigella infe ...[more]