Ontology highlight
ABSTRACT:
SUBMITTER: Bai L
PROVIDER: S-EPMC5489510 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Bai Lingling L Shao Hui H Wang Hongxing H Zhang Zhihui Z Su Chang C Dong Lijie L Yu Bo B Chen Xiteng X Li Xiaorong X Zhang Xiaomin X
Scientific reports 20170628 1
We previously demonstrated that mesenchymal stem cells (MSCs) ameliorated experimental autoimmune uveoretinitis (EAU) in rats. Recently, MSC-derived exosomes (MSC-Exo) were thought to carry functions of MSCs. In this study, we tested the effect of local administration of human MSC-Exo on established EAU in the same species. Rats with EAU induced by immunization with interphotoreceptor retinol-binding protein 1177-1191 peptide were treated by periocular injections of increasing doses of MSC-Exo s ...[more]