Unknown

Dataset Information

0

Mesenchymal Stem Cells-Derived Exosomes as Dexamethasone Delivery Vehicles for Autoimmune Hepatitis Therapy.


ABSTRACT: Exosomes (Exos) are nanosized vesicles (around 100 nm) that recently serve as a promising drug carrier with high biocompatibility and low immunogenicity. Previous studies showed that Exos secreted from mesenchymal stem cells (MSCs) provide protection for concanavalin A (Con A)-induced liver injury. In this study, the protective effect of Exos is confirmed, and dexamethasone (DEX)-incorporated Exos named Exo@DEX are prepared. It is then investigated whether Exo@DEX can function more efficiently compared to free drugs and naive Exos in a Con A-induced autoimmune hepatitis (AIH) mouse model. The results show that Exo@DEX efficiently improves the accumulation of DEX in AIH in the liver. These data suggest that Exo@DEX is a promising drug carrier for AIH and could have applications in other diseases.

SUBMITTER: Zhao J 

PROVIDER: S-EPMC8042336 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC6425428 | biostudies-literature
| S-EPMC8503317 | biostudies-literature
| S-EPMC5489510 | biostudies-literature
| S-EPMC6939658 | biostudies-literature
| S-EPMC10587508 | biostudies-literature
| S-EPMC4430381 | biostudies-literature
| S-EPMC5071792 | biostudies-other
| S-EPMC7119210 | biostudies-literature
| S-EPMC3931393 | biostudies-literature
| S-EPMC4918392 | biostudies-literature