Ontology highlight
ABSTRACT:
SUBMITTER: Gennaro M
PROVIDER: S-EPMC5489564 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Gennaro Mariangela M Mattiello Alessandro A Mazziotti Raffaele R Antonelli Camilla C Gherardini Lisa L Guzzetta Andrea A Berardi Nicoletta N Cioni Giovanni G Pizzorusso Tommaso T
Frontiers in neural circuits 20170629
Motor system development is characterized by an activity-dependent competition between ipsilateral and contralateral corticospinal tracts (CST). Clinical evidence suggests that age is crucial for developmental stroke outcome, with early lesions inducing a "maladaptive" strengthening of ipsilateral projections from the healthy hemisphere and worse motor impairment. Here, we investigated in developing rats the relation between lesion timing, motor outcome and CST remodeling pattern. We induced a f ...[more]