Ontology highlight
ABSTRACT:
SUBMITTER: Stefani C
PROVIDER: S-EPMC5490010 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Nature communications 20170623
Transendothelial cell macroaperture (TEM) tunnels control endothelium barrier function and are triggered by several toxins from pathogenic bacteria that provoke vascular leakage. Cellular dewetting theory predicted that a line tension of uncharacterized origin works at TEM boundaries to limit their widening. Here, by conducting high-resolution microscopy approaches we unveil the presence of an actomyosin cable encircling TEMs. We develop a theoretical cellular dewetting framework to interpret TE ...[more]