Ontology highlight
ABSTRACT:
SUBMITTER: Palma E
PROVIDER: S-EPMC549013 | biostudies-literature | 2005 Feb
REPOSITORIES: biostudies-literature
Palma Eleonora E Spinelli Gabriele G Torchia Gregorio G Martinez-Torres A A Ragozzino Davide D Miledi Ricardo R Eusebi Fabrizio F
Proceedings of the National Academy of Sciences of the United States of America 20050203 7
We studied the properties of GABAA receptors microtransplanted from the human temporal lobe epilepsy (TLE)-associated brain regions to Xenopus oocytes. Cell membranes, isolated from surgically resected brain specimens of drug-resistant TLE patients, were injected into frog oocytes, which rapidly incorporated human GABAA receptors, and any associated proteins, into their surface membrane. The receptors originating from different epileptic brain regions had a similar run-down but an affinity for G ...[more]