Browse
Submit Data
Databases
API
Help

Dataset Information

28 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Gold Electrodes Modified with Calix[4]arene for Electrochemical Determination of Dopamine in the Presence of Selected Neurotransmitters.

ABSTRACT: Here, we present an electrochemical sensor based on gold electrodes modified with calix[4]arene functionalized with carboxypiperidino groups at the upper rim. It has been demonstrated that these groups are involved in a complex formation with dopamine (DA) on the surface of gold electrodes. The supramolecular complex calix[4]arene-DA created on the gold electrode surface has been characterized electrochemically and the measuring conditions have been optimized. The presented sensor displayed a detection limit in the pM range. The DA determination was performed successfully in the presence of ascorbic acid, uric acid and selected neurotransmitters.

SUBMITTER: Kurzatkowska K

PROVIDER: S-EPMC5492125 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature

ACCESS DATA

Json Xml

Publications

Gold Electrodes Modified with Calix[4]arene for Electrochemical Determination of Dopamine in the Presence of Selected Neurotransmitters.

Kurzątkowska Katarzyna K Sayin Serkan S Yilmaz Mustafa M Radecka Hanna H Radecki Jerzy J

Sensors (Basel, Switzerland) 20170613 6

Here, we present an electrochemical sensor based on gold electrodes modified with calix[4]arene functionalized with carboxypiperidino groups at the upper rim. It has been demonstrated that these groups are involved in a complex formation with dopamine (DA) on the surface of gold electrodes. The supramolecular complex calix[4]arene-DA created on the gold electrode surface has been characterized electrochemically and the measuring conditions have been optimized. The presented sensor displayed a de ...[more]

PMID: 28608815

Similar Datasets

Diametric calix[6]arene-based phosphine gold(I) cavitands

Project description:We report the synthesis and characterization, in low polarity solvents, of a novel class of diametric phosphine gold(I) cavitands characterized by a 1,2,3-alternate geometry. Preliminary catalytic studies were performed on a model cycloisomerization of 1,6-enynes as a function of the relative orientation of the bonded gold(I) nuclei with respect to the macrocyclic cavity.

| S-EPMC8848346 | biostudies-literature

Multipodal Au-C grafting of calix[4]arene molecules on gold nanorods.

Project description:The interface robustness and spatial arrangement of functional molecules on metallic nanomaterials play a key part in the potential applications of functional nano-objects. The design of mechanically stable and electronically coupled attachments with the underlying metal is essential to bring specific desirable properties to the resulting hybrid materials. In this context, rigid multipodal platforms constitute a unique opportunity for the controllable grafting of functionality. Herein, we provide for the first time an in-depth description of the interface between gold nanorods and a chemically-grafted multipodal platform based on diazonium salts. Thanks to Raman and X-ray photoelectron spectroscopies and theoretical modeling, we deliver insights on the structural and electronic properties of the hybrid material. More importantly, it allows for the accurate assignment of Raman bands. The combination of experimental and theoretical results establishes the formation of four carbon-gold anchors for the calix[4]arene macrocycle leading to the exceptional stability of the functionalized nano-objects. Our results lay the foundations for the future design of robust and versatile platforms.

| S-EPMC11333938 | biostudies-literature

Efficient Electrochemical Sensor Based on Gold Nanoclusters/Carbon Ionic Liquid Crystal for Sensitive Determination of Neurotransmitters and Anti-Parkinson Drugs.

Project description:Purpose: Herein we introduce a simple and sensitive sensor for the electrochemical determination of neurotransmitters compounds and anti-Parkinson drugs. Methods: The electrochemical sensor (Au/CILCE) based on gold nanoclusters modified carbon ionic liquid crystal (ILC) electrode was characterized using scanning electron microscopy and voltammetry measurements. Results: The effect of ionic liquid type in the carbon paste composite for the electro-catalytic oxidation of L-dopa was evaluated. Highest current response was obtained in case of ILC compared to other studied kinds of ionic liquids. The effective combination of gold nanoclusters and ILC resulted in extra advantages including large surface area and high ionic conductivity of the nanocomposite. L-dopa is considered one of the most important prescribed medicines for treating Parkinson's disease. Moreover, a binary therapy using L-dopa and carbidopa proved effective and promising as it avoids the short comings of L-dopa mono-therapy for Parkinson's patients. The Au/CILCE can detect L-dopa in human serum in the linear concentration range of 0.1 μM to 90 μM with detection and quantification limits of 4.5 nM and 15.0 nM, respectively. Also, the Au/CILCE sensor can simultaneously and sensitively detect L-dopa in the presence of carbidopa with low detection limits. Conclusion: The sensor is advantageous to be applicable for electrochemical sensing of other biologically electroactive species.

| S-EPMC6983987 | biostudies-literature

Electrochemical Detection of Hydrazine Using Poly(dopamine)-Modified Electrodes.

Project description:We have developed a simple and selective method for the electrochemical detection of hydrazine (HZ) using poly(dopamine) (pDA)-modified indium tin oxide (ITO) electrodes. Modification with pDA was easily achieved by submerging the ITO electrode in a DA solution for 30 min. The electrocatalytic oxidation of HZ on the pDA-modified ITO electrode was measured by cyclic voltammetry. In buffer solution, the concentration range for linear HZ detection was 100 µM-10 mM, and the detection limit was 1 µM. The proposed method was finally used to determine HZ in tap water to simulate the analysis of real samples. This method showed good recovery (94%-115%) and was not affected by the other species present in the tap water samples.

| S-EPMC4883338 | biostudies-literature

Electrochemical Organophosphorus Pesticide Detection Using Nanostructured Gold-Modified Electrodes.

Project description:In this study, nanostructured gold was successfully prepared on a bare Au electrode using the electrochemical deposition method. Nanostructured gold provided more exposed active sites to facilitate the ion and electron transfer during the electrocatalytic reaction of organophosphorus pesticide (methyl parathion). The morphological and structural characterization of nanostructured gold was conducted using field-emission scanning electron microscopy (FESEM), X-ray photoelectron spectroscopy (XPS), and X-ray diffraction (XRD), which was further carried out to evaluate the electrocatalytic activity towards methyl parathion sensing. The electrochemical performance of nanostructured gold was investigated by electrochemical measurements (cyclic voltammetry (CV) and differential pulse voltammetry (DPV)). The proposed nanostructured gold-modified electrode exhibited prominent electrochemical methyl parathion sensing performance (including two linear concentration ranges from 0.01 to 0.5 ppm (R2 = 0.993) and from 0.5 to 4 ppm (R2 = 0.996), limit of detection of 5.9 ppb, excellent selectivity and stability), and excellent capability in determination of pesticide residue in real fruit and vegetable samples (bok choy and strawberry). The study demonstrated that the presented approach to fabricate a nanostructured gold-modified electrode could be practically applied to detect pesticide residue in agricultural products via integrating the electrochemical and gas chromatography coupled with mass spectrometry (GC/MS-MS) analysis.

| S-EPMC9787336 | biostudies-literature

5,17-Diformyl-25,26,27,28-tetra-propoxy-calix[4]arene.

Project description:The title compound, C42H48O6, was obtained via formyl-ation of 25,26,27,28-tetra-propoxycalix[4]arene with dichloro-methyl methyl ether and tin tetra-chloride. It adopts a pinched cone conformation, which leads to an open cavity. The two opposite aromatic rings bearing formyl groups are almost parallel, making a dihedral angle of 29.1?(2)°. The other pair of opposite rings are close to being perpendicular, making a dihedral angle of 73.6?(1)°. Adjacent rings are almost perpendicular, making dihedral angles of 78.8?(2), 81.6?(1), 78.2?(1) and 74.7?(1)°.

| S-EPMC3588550 | biostudies-other

Ion pair-induced conformational motion in calix[4]arene-strapped calix[4]pyrroles.

Project description:In order to understand the still-poorly understood interplay between calix[4]arene conformations and cation and anion recognition in multicomponent systems, the ion pair receptors 1 and 2 were synthesized. In solution and in the solid state, the calix[4]arene subunit of receptor 1 adopts a cone conformation, while that of 2 interconverts between the cone and the partial cone conformation. These geometric features differ from previous systems where the calix[4]arene moiety was locked in the 1,3-alternate conformation. A combination of 1H NMR spectroscopic analyses and single crystal X-ray diffraction studies reveal that receptor 1 binds the fluoride and the chloride anion via significantly different binding modes, displaying, for instance, 1 : 1 and 2 : 3 binding stoichiometries with CsF and CsCl, respectively. In the case of 2, the conformation of the calix[4]arene constituent of 2 is highly dependent on the size and quantity of anions present. For example, upon treatment of 2 with the fluoride anion (as both the TBA+ and Cs+ salts), the calix[4]arene unit coexists as cone and partial cone conformers that are inter-convertible. In the presence of excess CsF, the aromatic rings of the calix[4]arene subunit becomes locked in the pinched cone conformation with the result that an ion pair-mediated coordination polymer is formed. In the presence of excess CsCl, the calix[4]arene unit of 2 adopts only the partial cone conformation stabilized by aryl CH-anion hydrogen bonding interactions. The present systems constitute a rare set of related receptors wherein the effects of conformational changes are so tightly coupled with ion recognition.

| S-EPMC5811093 | biostudies-literature

Calix[6]arene-based atropoisomeric pseudo[2]rotaxanes.

Project description:Some examples of atropoisomeric pseudorotaxanes in which the isomerism arises by the different conformations adopted by the wheel are reported here. Upon threading hexahexyloxycalix[6]arene 1 with ammonium axles 2+ or 3+ , bearing biphenyl or trifluoromethylbenzyl moieties, respectively, two atropoisomeric pseudorotaxanes were formed in which the calix[6]-wheel 1 adopts the 1,2,3-alternate and cone conformations. The interconversion between them cannot be obtained by simple rotation around the ArCH2Ar bonds of the calixarene wheel, which is blocked by the presence of the axle inside its cavity. Therefore, it can only be obtained through a mechanism of de-threading/re-threading of the axle. In all the examined cases, the 1,2,3-alternate and cone atropoisomers are, respectively, the kinetic and the thermodynamic ones.

| S-EPMC6122310 | biostudies-literature

Electrochemical detection of dopamine using periodic cylindrical gold nanoelectrode arrays.

Project description:Dopamine is a key molecule in neurotransmission and has been known to be responsible for several neurological diseases. Hence, its sensitive and selective detection is important for the early diagnosis of diseases related to abnormal levels of dopamine. In this study, we reported a new cylindrical gold nanoelectrode (CAuNE) platform fabricated via sequential laser interference lithography and electrochemical deposition. Among the fabricated electrodes, CAuNEs with a diameter of 700 nm, 150 s deposited, was found to be the best for electrochemical dopamine detection. According to cyclic voltammetry results, the linear range of the CAuNE-700 nm was 1-100 µM of dopamine with a limit of detection (LOD) of 5.83 µM. Moreover, owing to the homogeneous periodic features of CAuNEs, human neural cells were successfully cultured and maintained for more than 5 days in vitro without the use of any extracellular matrix proteins and dopamine was detectable in the presence of these cells on the electrode. Therefore, we concluded that the developed dopamine sensing platform CAuNE can be used for many applications including early diagnosis of neurological diseases; function tests of dopaminergic neurons derived from various stem cell sources; and toxicity assessments of drugs, chemicals, and nanomaterials on human neuronal cells.

| S-EPMC6145913 | biostudies-literature

Anomalous Trends in Nucleic Acid-Based Electrochemical Biosensors with Nanoporous Gold Electrodes.

Project description:Molecular diagnostics have significantly advanced the early detection of diseases, where electrochemical sensing of biomarkers has shown considerable promise. For a nucleic acid-based electrochemical sensor with signal-off behavior, the performance is evaluated by percent signal suppression (% ss), which indicates the change in current after hybridization. The % ss is generally due to more redox molecules (e.g., methylene blue) associating with the probe DNA bases in the single-strand form than the double-strand form upon hybridization with the target nucleic acid. Nanostructured electrodes generally enhance electrochemical sensor performance via several mechanisms, including increased number of capture probes per electrode volume and unique nanoscale transport phenomena. Here, we employ nanoporous gold (np-Au) as a model electrode material to study the influence of probe immobilization solution concentration on sensor performance and the underlying mechanisms. Unlike planar gold (pl-Au) electrodes, where % ss reaches a steady state with increasing concentration of the grafting solution, the % ss displays peak performance at certain grafting solution concentrations followed by rapid deterioration and reversal of the % ss polarity, suggesting an unexpected case of increased charge transfer upon hybridization. Fluorometric assessments of electrochemically desorbed nucleic acids for different electrode morphologies reveal that a significant amount of DNA molecules (unhybridized and hybridized) remain within the nanopores posthybridization. Analysis of electrochemical signals (e.g., square wave voltammogram shape) suggests that the large unbound nucleic acid concentration may be altering the modes of methylene blue interaction with the nucleic acids and charge transfer to the electrode surfaces.

| S-EPMC6751010 | biostudies-literature

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data