Multiparametric Imaging of Tumor Hypoxia and Perfusion with ¹⁸F-Fluoromisonidazole Dynamic PET in Head and Neck Cancer.

ABSTRACT: Tumor hypoxia and perfusion are independent prognostic indicators of patient outcome. We developed the methodology for and investigated the utility of multiparametric imaging of tumor hypoxia and perfusion with ¹⁸F-fluoromisonidazole (¹⁸F-FMISO) dynamic PET (dPET) in head and neck cancer. Methods: One hundred twenty head and neck cancer patients underwent 0- to 30-min ¹⁸F-FMISO dPET in a customized immobilization mask, followed by 10-min static acquisitions starting at 93 ± 6 and 160 ± 13 min after injection. A total of 248 lesions (≥2 cm³) were analyzed. Voxelwise pharmacokinetic modeling was conducted using an irreversible 1-plasma 2-tissue-compartment model to calculate surrogate biomarkers of tumor hypoxia (k₃), perfu

SUBMITTER: Grkovski M 

PROVIDER: S-EPMC5493008 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature