Ontology highlight
ABSTRACT:
SUBMITTER: Kitamura T
PROVIDER: S-EPMC5493329 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Kitamura Takashi T Ogawa Sachie K SK Roy Dheeraj S DS Okuyama Teruhiro T Morrissey Mark D MD Smith Lillian M LM Redondo Roger L RL Tonegawa Susumu S
Science (New York, N.Y.) 20170401 6333
Episodic memories initially require rapid synaptic plasticity within the hippocampus for their formation and are gradually consolidated in neocortical networks for permanent storage. However, the engrams and circuits that support neocortical memory consolidation have thus far been unknown. We found that neocortical prefrontal memory engram cells, which are critical for remote contextual fear memory, were rapidly generated during initial learning through inputs from both the hippocampal-entorhina ...[more]