Ontology highlight
ABSTRACT:
SUBMITTER: Zheng Z
PROVIDER: S-EPMC5493393 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Zheng Zhong Z Huang Xi-Ping XP Mangano Thomas J TJ Zou Rodger R Chen Xin X Zaidi Saheem A SA Roth Bryan L BL Stevens Raymond C RC Katritch Vsevolod V
Journal of medicinal chemistry 20170403 7
The ongoing epidemics of opioid overdose raises an urgent need for effective antiaddiction therapies and addiction-free painkillers. The κ-opioid receptor (KOR) has emerged as a promising target for both indications, raising demand for new chemotypes of KOR antagonists as well as G-protein-biased agonists. We employed the crystal structure of the KOR-JDTic complex and ligand-optimized structural templates to perform virtual screening of available compound libraries for new KOR ligands. The prosp ...[more]