Ontology highlight
ABSTRACT:
SUBMITTER: Bist P
PROVIDER: S-EPMC5493756 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Bist Pradeep P Cheong Wan Shoo WS Ng Aylwin A Dikshit Neha N Kim Bae-Hoon BH Pulloor Niyas Kudukkil NK Khameneh Hanif Javanmard HJ Hedl Matija M Shenoy Avinash R AR Balamuralidhar Vanniarajan V Malik Najib Bin Abdul NBA Hong Michelle M Neutzner Albert A Chin Keh-Chuang KC Kobayashi Koichi S KS Bertoletti Antonio A Mortellaro Alessandra A Abraham Clara C MacMicking John D JD Xavier Ramnik J RJ Sukumaran Bindu B
Nature communications 20170628
Optimal regulation of the innate immune receptor nucleotide-binding oligomerization domain-containing protein 2 (NOD2) is essential for controlling bacterial infections and inflammatory disorders. Chronic NOD2 stimulation induces non-responsiveness to restimulation, termed NOD2-induced tolerance. Although the levels of the NOD2 adaptor, RIP2, are reported to regulate both acute and chronic NOD2 signalling, how RIP2 levels are modulated is unclear. Here we show that ZNRF4 induces K48-linked ubiqu ...[more]