Ontology highlight
ABSTRACT:
SUBMITTER: Telesio G
PROVIDER: S-EPMC5751184 | biostudies-other | 2017 Dec
REPOSITORIES: biostudies-other
Telesio Gianluca G Scudiero Ivan I Pizzulo Maddalena M Mazzone Pellegrino P Zotti Tiziana T Voccola Serena S Polvere Immacolata I Vito Pasquale P Stilo Romania R
International journal of molecular sciences 20171201 12
The three CARD-containing MAGUK (CARMA) proteins function as scaffolding molecules that regulate activation of the pro-inflammatory transcription factor NF-κB. Recently, mutations in CARMA2 have been linked to psoriasis susceptibility due to their acquired altered capacity to activate NF-κB. By means of two-hybrid screening with yeast, we identified RING finger protein 7 (RNF7) as an interactor of CARMA2. We present evidence that RNF7 functions as a negative regulator of the NF-κB-activating cap ...[more]