Ontology highlight
ABSTRACT:
SUBMITTER: Molloy CT
PROVIDER: S-EPMC5493992 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Molloy Caitlyn T CT Andonian Jennifer S JS Seltzer Harrison M HM Procario Megan C MC Watson Michael E ME Weinberg Jason B JB
Virology 20170411
CD8 T cells are key components of the immune response to viruses, but their roles in the pathogenesis of adenovirus respiratory infection have not been characterized. We used mouse adenovirus type 1 (MAV-1) to define CD8 T cell contributions to the pathogenesis of adenovirus respiratory infection. CD8 T cell deficiency in β2m<sup>-/-</sup> mice had no effect on peak viral replication in lungs, but clearance of virus was delayed in β2m<sup>-/-</sup> mice. Virus-induced weight loss and increases i ...[more]