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Contributions of CD8 T cells to the pathogenesis of mouse adenovirus type 1 respiratory infection.


ABSTRACT: CD8 T cells are key components of the immune response to viruses, but their roles in the pathogenesis of adenovirus respiratory infection have not been characterized. We used mouse adenovirus type 1 (MAV-1) to define CD8 T cell contributions to the pathogenesis of adenovirus respiratory infection. CD8 T cell deficiency in ?2m-/- mice had no effect on peak viral replication in lungs, but clearance of virus was delayed in ?2m-/- mice. Virus-induced weight loss and increases in bronchoalveolar lavage fluid total protein, IFN-?, TNF-?, IL-10, CCL2, and CCL5 concentrations were less in ?2m-/- mice than in controls. CD8 T cell depletion had similar effects on virus clearance, weight loss, and inflammation. Deficiency of IFN-? or perforin had no effect on viral replication or inflammation, but perforin-deficient mice were partially protected from weight loss. CD8 T cells promote MAV-1-induced pulmonary inflammation via a mechanism that is independent of direct antiviral effects.

SUBMITTER: Molloy CT 

PROVIDER: S-EPMC5493992 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature

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Contributions of CD8 T cells to the pathogenesis of mouse adenovirus type 1 respiratory infection.

Molloy Caitlyn T CT   Andonian Jennifer S JS   Seltzer Harrison M HM   Procario Megan C MC   Watson Michael E ME   Weinberg Jason B JB  

Virology 20170411


CD8 T cells are key components of the immune response to viruses, but their roles in the pathogenesis of adenovirus respiratory infection have not been characterized. We used mouse adenovirus type 1 (MAV-1) to define CD8 T cell contributions to the pathogenesis of adenovirus respiratory infection. CD8 T cell deficiency in β2m<sup>-/-</sup> mice had no effect on peak viral replication in lungs, but clearance of virus was delayed in β2m<sup>-/-</sup> mice. Virus-induced weight loss and increases i  ...[more]

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