Ontology highlight
ABSTRACT:
SUBMITTER: Schmidt ME
PROVIDER: S-EPMC5766251 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Schmidt Megan E ME Knudson Cory J CJ Hartwig Stacey M SM Pewe Lecia L LL Meyerholz David K DK Langlois Ryan A RA Harty John T JT Varga Steven M SM
PLoS pathogens 20180102 1
Memory CD8 T cells can provide protection from re-infection by respiratory viruses such as influenza and SARS. However, the relative contribution of memory CD8 T cells in providing protection against respiratory syncytial virus (RSV) infection is currently unclear. To address this knowledge gap, we utilized a prime-boost immunization approach to induce robust memory CD8 T cell responses in the absence of RSV-specific CD4 T cells and antibodies. Unexpectedly, RSV infection of mice with pre-existi ...[more]