Relative predicted protein levels of functionally associated proteins are conserved across organisms.
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ABSTRACT:
SUBMITTER: Lithwick G
PROVIDER: S-EPMC549420 | biostudies-literature | 2005
REPOSITORIES: biostudies-literature
Publications
Relative predicted protein levels of functionally associated proteins are conserved across organisms.
Lithwick Gila G Margalit Hanah H
Nucleic acids research 20050217 3
We show that the predicted protein levels of functionally related proteins change in a coordinated fashion over many unicellular organisms. For each protein, we created a profile containing a protein abundance measure in each of a set of organisms. We show that for functionally related proteins these profiles tend to be correlated. Using the Codon Adaptation Index as a predictor of protein abundance in 48 unicellular organisms, we demonstrated this phenomenon for two types of functional relation ...[more]
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