Ontology highlight
ABSTRACT:
SUBMITTER: Moutsopoulos NM
PROVIDER: S-EPMC5494261 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Moutsopoulos Niki M NM Zerbe Christa S CS Wild Teresa T Dutzan Nicolas N Brenchley Laurie L DiPasquale Giovanni G Uzel Gulbu G Axelrod Karen C KC Lisco Andrea A Notarangelo Lucia D LD Hajishengallis George G Notarangelo Luigi D LD Holland Steven M SM
The New England journal of medicine 20170301 12
A patient with leukocyte adhesion deficiency type 1 (LAD1) had severe periodontitis and an intractable, deep, nonhealing sacral wound. We had previously found a dominant interleukin-23-interleukin-17 signature at inflamed sites in humans with LAD1 and in mouse models of the disorder. Blockade of this pathway in mouse models has resulted in resolution of the immunopathologic condition. We treated our patient with ustekinumab, an antibody that binds the p40 subunit of interleukin-23 and interleuki ...[more]