Ontology highlight
ABSTRACT:
SUBMITTER: Eede P
PROVIDER: S-EPMC7054677 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Eede Pascale P Obst Juliane J Benke Eileen E Yvon-Durocher Genevieve G Richard Bernhard C BC Gimber Niclas N Schmoranzer Jan J Böddrich Annett A Wanker Erich E EE Prokop Stefan S Heppner Frank L FL
EMBO reports 20200130 3
Pathological aggregation of amyloid-β (Aβ) is a main hallmark of Alzheimer's disease (AD). Recent genetic association studies have linked innate immune system actions to AD development, and current evidence suggests profound gender differences in AD pathogenesis. Here, we characterise gender-specific pathologies in the APP23 AD-like mouse model and find that female mice show stronger amyloidosis and astrogliosis compared with male mice. We tested the gender-specific effect of lack of IL12p40, th ...[more]