Variation in the strength of selected codon usage bias among bacteria.
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ABSTRACT:
SUBMITTER: Sharp PM
PROVIDER: S-EPMC549432 | biostudies-literature | 2005
REPOSITORIES: biostudies-literature
Publications
Variation in the strength of selected codon usage bias among bacteria.
Sharp Paul M PM Bailes Elizabeth E Grocock Russell J RJ Peden John F JF Sockett R Elizabeth RE
Nucleic acids research 20050223 4
Among bacteria, many species have synonymous codon usage patterns that have been influenced by natural selection for those codons that are translated more accurately and/or efficiently. However, in other species selection appears to have been ineffective. Here, we introduce a population genetics-based model for quantifying the extent to which selection has been effective. The approach is applied to 80 phylogenetically diverse bacterial species for which whole genome sequences are available. The ...[more]
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