Ontology highlight
ABSTRACT:
SUBMITTER: Abend A
PROVIDER: S-EPMC5494505 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Abend Alon A Shkedi Omer O Fertouk Michal M Caspi Lilac H LH Kehat Izhak I
EMBO reports 20170606 7
A pathologic osteochondrogenic differentiation of vascular smooth muscle cells (VSMCs) promotes arterial calcifications, a process associated with significant morbidity and mortality. The molecular pathways promoting this pathology are not completely understood. We studied VSMCs, mouse aortic rings, and human aortic valves and showed here that histone deacetylase 4 (HDAC4) is upregulated early in the calcification process. Gain- and loss-of-function assays demonstrate that HDAC4 is a positive re ...[more]