Ontology highlight
ABSTRACT:
SUBMITTER: Dierickx P
PROVIDER: S-EPMC5494509 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Dierickx Pieterjan P Vermunt Marit W MW Muraro Mauro J MJ Creyghton Menno P MP Doevendans Pieter A PA van Oudenaarden Alexander A Geijsen Niels N Van Laake Linda W LW
EMBO reports 20170523 7
Cell-autonomous circadian oscillations strongly influence tissue physiology and pathophysiology of peripheral organs including the heart, in which the circadian clock is known to determine cardiac metabolism and the outcome of for instance ischemic stress. Human pluripotent stem cells represent a powerful tool to study developmental processes <i>in vitro</i>, but the extent to which human embryonic stem (ES) cell-derived cardiomyocytes establish circadian rhythmicity in the absence of a systemic ...[more]