Transcriptional and functional profiling of human embryonic stem cell-derived cardiomyocytes.
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ABSTRACT:
SUBMITTER: Cao F
PROVIDER: S-EPMC2565131 | biostudies-literature | 2008
REPOSITORIES: biostudies-literature
Publications
Transcriptional and functional profiling of human embryonic stem cell-derived cardiomyocytes.
Cao Feng F Wagner Roger A RA Wilson Kitchener D KD Xie Xiaoyan X Fu Ji-Dong JD Drukker Micha M Lee Andrew A Li Ronald A RA Gambhir Sanjiv S SS Weissman Irving L IL Robbins Robert C RC Wu Joseph C JC
PloS one 20081022 10
Human embryonic stem cells (hESCs) can serve as a potentially limitless source of cells that may enable regeneration of diseased tissue and organs. Here we investigate the use of human embryonic stem cell-derived cardiomyocytes (hESC-CMs) in promoting recovery from cardiac ischemia reperfusion injury in a mouse model. Using microarrays, we have described the hESC-CM transcriptome within the spectrum of changes that occur between undifferentiated hESCs and fetal heart cells. The hESC-CMs expresse ...[more]
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