Ontology highlight
ABSTRACT:
SUBMITTER: Miyoshi S
PROVIDER: S-EPMC5494517 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Miyoshi Sadanori S Tezuka Tohru T Arimura Sumimasa S Tomono Taro T Okada Takashi T Yamanashi Yuji Y
EMBO molecular medicine 20170701 7
Amyotrophic lateral sclerosis (ALS) is a progressive, multifactorial motor neurodegenerative disease with severe muscle atrophy. The glutamate release inhibitor riluzole is the only medication approved by the FDA, and prolongs patient life span by a few months, testifying to a strong need for new treatment strategies. In ALS, motor neuron degeneration first becomes evident at the motor nerve terminals in neuromuscular junctions (NMJs), the cholinergic synapse between motor neuron and skeletal mu ...[more]