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A sialic acid-targeted near-infrared theranostic for signal activation based intraoperative tumor ablation.

ABSTRACT: Agents enabling tumor staging are valuable for cancer surgery. Herein, a targetable sialic acid-armed near-infrared profluorophore (SA-pNIR) is reported for fluorescence guided tumor detection. SA-pNIR consists of a sialic acid entity effective for in vivo tumor targeting and a profluorophore which undergoes lysosomal acidity-triggered fluorogenic isomerization. SA-pNIR displays a number of advantageous biomedical properties in mice, e.g. high tumor-to-normal tissue signal contrast, long-term retention in tumors and low systemic toxicity. In addition, SA-pNIR effectively converts NIR light into cytotoxic heat in cells, suggesting tumor-activatable photothermal therapy. With high performance tumor illumination and lysosome-activatable photothermal properties, SA-pNIR is a promising agent for detection and photothermal ablation of surgically exposed tumors.

SUBMITTER: Wu X

PROVIDER: S-EPMC5494541 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature

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A sialic acid-targeted near-infrared theranostic for signal activation based intraoperative tumor ablation.

Wu Xuanjun X Yu Mingzhu M Lin Bijuan B Xing Hongjie H Han Jiahuai J Han Shoufa S

Chemical science 20140925 1

Agents enabling tumor staging are valuable for cancer surgery. Herein, a targetable sialic acid-armed near-infrared profluorophore (SA-pNIR) is reported for fluorescence guided tumor detection. SA-pNIR consists of a sialic acid entity effective for <i>in vivo</i> tumor targeting and a profluorophore which undergoes lysosomal acidity-triggered fluorogenic isomerization. SA-pNIR displays a number of advantageous biomedical properties in mice, <i>e.g.</i> high tumor-to-normal tissue signal contrast ...[more]

PMID: 28706639

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