Ontology highlight
ABSTRACT:
SUBMITTER: Santiago AG
PROVIDER: S-EPMC5495265 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Santiago Ace George AG Chen Tai-Yen TY Genova Lauren A LA Jung Won W George Thompson Alayna M AM McEvoy Megan M MM Chen Peng P
Proceedings of the National Academy of Sciences of the United States of America 20170612 26
Multicomponent efflux complexes constitute a primary mechanism for Gram-negative bacteria to expel toxic molecules for survival. As these complexes traverse the periplasm and link inner and outer membranes, it remains unclear how they operate efficiently without compromising periplasmic plasticity. Combining single-molecule superresolution imaging and genetic engineering, we study in living <i>Escherichia coli</i> cells the tripartite efflux complex CusCBA of the resistance-nodulation-division f ...[more]