Rab2 promotes autophagic and endocytic lysosomal degradation.
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ABSTRACT:
SUBMITTER: Lorincz P
PROVIDER: S-EPMC5496615 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Publications
Rab2 promotes autophagic and endocytic lysosomal degradation.
Lőrincz Péter P Tóth Sarolta S Benkő Péter P Lakatos Zsolt Z Boda Attila A Glatz Gábor G Zobel Martina M Bisi Sara S Hegedűs Krisztina K Takáts Szabolcs S Scita Giorgio G Juhász Gábor G
The Journal of cell biology 20170508 7
Rab7 promotes fusion of autophagosomes and late endosomes with lysosomes in yeast and metazoan cells, acting together with its effector, the tethering complex HOPS. Here we show that another small GTPase, Rab2, is also required for autophagosome and endosome maturation and proper lysosome function in <i>Drosophila melanogaster</i> We demonstrate that Rab2 binds to HOPS, and that its active, GTP-locked form associates with autolysosomes. Importantly, expression of active Rab2 promotes autolysosom ...[more]
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