Ontology highlight
ABSTRACT:
SUBMITTER: Kenny EF
PROVIDER: S-EPMC5496738 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Kenny Elaine F EF Herzig Alf A Krüger Renate R Muth Aaron A Mondal Santanu S Thompson Paul R PR Brinkmann Volker V Bernuth Horst von HV Zychlinsky Arturo A
eLife 20170602
Neutrophils release neutrophil extracellular traps (NETs) which ensnare pathogens and have pathogenic functions in diverse diseases. We examined the NETosis pathways induced by five stimuli; PMA, the calcium ionophore A23187, nigericin, <i>Candida albicans</i> and Group B Streptococcus. We studied NET production in neutrophils from healthy donors with inhibitors of molecules crucial to PMA-induced NETs including protein kinase C, calcium, reactive oxygen species, the enzymes myeloperoxidase (MPO ...[more]