Dataset Information

Circulating ferritin concentrations and risk of type 2 diabetes in Japanese individuals.

ABSTRACT:

Aims/introduction

Higher iron storage has been linked to an increased risk of type 2 diabetes, but little is known about the mediator of this association. Here, we prospectively investigated the association between circulating ferritin, a marker of iron storage, and the incidence of type 2 diabetes among Japanese individuals.

Materials and methods

The participants were 4,754 employees who attended a comprehensive health check-up in 2008-2009 and donated blood for the study. During 5 years of follow up, diabetes was identified based on plasma glucose, glycated hemoglobin and self-report. Two controls matched to each case on sex, age and date of check-up were randomly chosen using density sampling, giving 327 cases and 641 controls with ferritin measurement. Cox proportional hazards regression was used to estimate the hazard ratio while adjusting for a series of potential confounders or mediators.

Results

Elevated serum ferritin levels were associated with a significantly increased risk of type 2 diabetes, with the hazard ratio adjusted for known risk factors in the highest vs lowest quartile of 1.42 (95% confidence interval: 1.03-1.96). This association was unchanged after adjustment for C-reactive protein and adiponectin, but attenuated after adjustment for liver enzyme and insulin resistance (hazard ratio 1.04). The ferritin-diabetes association was confined to non-obese participants.

Conclusions

These results suggest that elevated iron storage is associated with increased risk of type 2 diabetes in normal weight individuals, and that this association is partly mediated through liver dysfunction and resulting insulin resistance.

SUBMITTER: Akter S

PROVIDER: S-EPMC5497053 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature

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Publications

Circulating ferritin concentrations and risk of type 2 diabetes in Japanese individuals.

Akter Shamima S Nanri Akiko A Kuwahara Keisuke K Matsushita Yumi Y Nakagawa Tohru T Konishi Maki M Honda Toru T Yamamoto Shuichiro S Hayashi Takeshi T Noda Mitsuhiko M Mizoue Tetsuya T

Journal of diabetes investigation 20170306 4

<h4>Aims/introduction</h4>Higher iron storage has been linked to an increased risk of type 2 diabetes, but little is known about the mediator of this association. Here, we prospectively investigated the association between circulating ferritin, a marker of iron storage, and the incidence of type 2 diabetes among Japanese individuals.<h4>Materials and methods</h4>The participants were 4,754 employees who attended a comprehensive health check-up in 2008-2009 and donated blood for the study. During ...[more]

PMID: 28060459

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Dataset Information

Circulating ferritin concentrations and risk of type 2 diabetes in Japanese individuals.

Aims/introduction

Materials and methods

Results

Conclusions

Publications

Circulating ferritin concentrations and risk of type 2 diabetes in Japanese individuals.

Similar Datasets

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