Ontology highlight
ABSTRACT:
SUBMITTER: Manring HR
PROVIDER: S-EPMC5498325 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Manring Heather R HR Carter Olivia A OA Ackermann Maegen A MA
Biophysical reviews 20170329 3
The obscurin family of polypeptides is essential for normal striated muscle function and contributes to the pathogenesis of fatal diseases, including cardiomyopathies and cancers. The single mammalian obscurin gene, OBSCN, gives rise to giant (∼800 kDa) and smaller (∼40-500 kDa) proteins that are composed of tandem adhesion and signaling motifs. Mammalian obscurin proteins are expressed in a variety of cell types, including striated muscles, and localize to distinct subcellular compartments wher ...[more]