Novel oestrogen receptor ?-selective ligand reduces obesity and depressive-like behaviour in ovariectomized mice.

ABSTRACT: Hormonal changes due to menopause can cause various health problems including weight gain and depressive symptoms. Multiple lines of evidence indicate that oestrogen receptors (ERs) play a major role in postmenopausal obesity and depression. However, little is known regarding the ER subtype-specific effects on obesity and depressive symptoms. To delineate potential effects of ER? activation in postmenopausal women, we investigated the effects of a novel oestrogen receptor ?-selective ligand (C-1) in ovariectomized mice. Uterine weight, depressive behaviour, and weight gain were examined in sham-operated control mice and ovariectomized mice administered placebo, C-1, or 17?-oestradiol (E2). Administration of C-1 or E2 reduced body weight gain and depressive-like behaviour in ovariectomized mice, as assessed by the forced swim test. In addition, administration of E2 to ovariectomized mice increased uterine weight, but administration of C-1 did not result in a significant increase in uterine weight. These results suggest that the selective activation of ER? in ovariectomized mice may have protective effects against obesity and depressive-like behaviour without causing an increase in uterine weight. The present findings raise the possibility of the application of ER?-ligands such as C-1 as a novel treatment for obesity and depression in postmenopausal women.

SUBMITTER: Sasayama D 

PROVIDER: S-EPMC5498485 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature