Ontology highlight
ABSTRACT:
SUBMITTER: Nagarajan P
PROVIDER: S-EPMC5499190 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Nagarajan Prabha P Prevost Christopher T CT Stein Alexis A Kasimer Rachel R Kalifa Lidza L Sia Elaine A EA
Genetics 20170426 2
The structure-specific nuclease, Rad27p/FEN1, plays a crucial role in DNA repair and replication mechanisms in the nucleus. Genetic assays using the <i>rad27-∆</i> mutant have shown altered rates of DNA recombination, microsatellite instability, and point mutation in mitochondria. In this study, we examined the role of Rad27p in mitochondrial mutagenesis and double-strand break (DSB) repair in <i>Saccharomyces cerevisiae</i> Our findings show that Rad27p is essential for efficient mitochondrial ...[more]