Ontology highlight
ABSTRACT:
SUBMITTER: Kadyrov FA
PROVIDER: S-EPMC2302834 | biostudies-literature | 2007 Dec
REPOSITORIES: biostudies-literature
Kadyrov Farid A FA Holmes Shannon F SF Arana Mercedes E ME Lukianova Olga A OA O'Donnell Mike M Kunkel Thomas A TA Modrich Paul P
The Journal of biological chemistry 20071019 51
MutL homologs are crucial for mismatch repair and genetic stability, but their function is not well understood. Human MutLalpha (MLH1-PMS2 heterodimer) harbors a latent endonuclease that is dependent on the integrity of a PMS2 DQHA(X)2E(X)4E motif (Kadyrov, F. A., Dzantiev, L., Constantin, N., and Modrich, P. (2006) Cell 126, 297-308). This sequence element is conserved in many MutL homologs, including the PMS1 subunit of Saccharomyces cerevisiae MutLalpha, but is absent in MutL proteins from ba ...[more]