Selective analysis of cancer-cell intrinsic transcriptional traits defines novel clinically relevant subtypes of colorectal cancer.
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ABSTRACT:
SUBMITTER: Isella C
PROVIDER: S-EPMC5499209 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Publications
Selective analysis of cancer-cell intrinsic transcriptional traits defines novel clinically relevant subtypes of colorectal cancer.
Isella Claudio C Brundu Francesco F Bellomo Sara E SE Galimi Francesco F Zanella Eugenia E Porporato Roberta R Petti Consalvo C Fiori Alessandro A Orzan Francesca F Senetta Rebecca R Boccaccio Carla C Ficarra Elisa E Marchionni Luigi L Trusolino Livio L Medico Enzo E Bertotti Andrea A
Nature communications 20170531
Stromal content heavily impacts the transcriptional classification of colorectal cancer (CRC), with clinical and biological implications. Lineage-dependent stromal transcriptional components could therefore dominate over more subtle expression traits inherent to cancer cells. Since in patient-derived xenografts (PDXs) stromal cells of the human tumour are substituted by murine counterparts, here we deploy human-specific expression profiling of CRC PDXs to assess cancer-cell intrinsic transcripti ...[more]
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