FGFR1 expression defines clinically distinct subtypes in pancreatic cancer.

ABSTRACT: BACKGROUND:The clinical significance of fibroblast growth factor receptor 1 (FGFR1) protein expression in pancreatic cancer is largely unknown. In this study, we aimed investigate the clinical significance of FGFR1 expression in pancreatic cancer. METHODS:First, we investigated the relationship between FGFR pathway gene expression and clinicopathological data in three pancreatic cancer cohorts containing 313 cases. Subsequently, to confirm the findings from the discovery cohorts, we performed immunohistochemistry (IHC) of FGFR1 protein in a validation cohort of 205 pancreatic cancer cases. RESULTS:In discovery cohort 1, FGFR1 and Klotho beta (KLB) overexpression was associated with low tumor stage (P?

SUBMITTER: Haq F 

PROVIDER: S-EPMC6311038 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature