Crystal structures of 2-[(4,6-di-amino-pyrimidin-2-yl)sulfan-yl]-N-(2,4-di-methyl-phen-yl)acetamide and 2-[(4,6-di-amino-pyrimidin-2-yl)sulfan-yl]-N-(3-meth-oxy-phen-yl)acetamide.

ABSTRACT: In the title compounds, C₁₄H₁₇N₅OS (I) and C₁₃H₁₅N₅O₂S (II), the dihedral angle between the pyrimidine and benzene rings is 58.64 (8)° in (I) and 78.33 (9)° in (II). In both compounds, there is an intra-molecular C-H⋯O hydrogen bond, and in (II) there is also an intra-molecular N-H⋯N hydrogen bond present. In the crystals of both compounds, a pair of N-H⋯N hydrogen bonds links the individual mol-ecules to form inversion dimers with R₂²(8) ring motifs. In (I), the dimers are linked by N-H⋯O and C-H⋯O hydrogen bonds, enclosing R₂¹(14), R₂¹(11) and R₂¹(7) ring motifs, forming layers parallel to the (100) plane. There is also an N-H⋯π inter-action present within the layer. In (II), the inversion dimers are linked by N-H⋯O hydrogen bonds enclosing an R₄⁴(18) ring motif. The presence of N-H⋯O and C-H⋯O hydrogen bonds generate an R₂¹(6) ring motif. The combination of these various hydrogen bonds results in the formation of layers parallel to the (1-11) plane.

SUBMITTER: Choudhury M 

PROVIDER: S-EPMC5499277 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature