Dataset Information

In-vivo X-ray Dark-Field Chest Radiography of a Pig.

ABSTRACT: X-ray chest radiography is an inexpensive and broadly available tool for initial assessment of the lung in clinical routine, but typically lacks diagnostic sensitivity for detection of pulmonary diseases in their early stages. Recent X-ray dark-field (XDF) imaging studies on mice have shown significant improvements in imaging-based lung diagnostics. Especially in the case of early diagnosis of chronic obstructive pulmonary disease (COPD), XDF imaging clearly outperforms conventional radiography. However, a translation of this technique towards the investigation of larger mammals and finally humans has not yet been achieved. In this letter, we present the first in-vivo XDF full-field chest radiographs (32?×?35?cm²) of a living pig, acquired with clinically compatible parameters (40?s scan time, approx. 80 µSv dose). For imaging, we developed a novel high-energy XDF system that overcomes the limitations of currently established setups. Our XDF radiographs yield sufficiently high image quality to enable radiographic evaluation of the lungs. We consider this a milestone in the bench-to-bedside translation of XDF imaging and expect XDF imaging to become an invaluable tool in clinical practice, both as a general chest X-ray modality and as a dedicated tool for high-risk patients affected by smoking, industrial work and indoor cooking.

SUBMITTER: Gromann LB

PROVIDER: S-EPMC5500502 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature

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Publications

In-vivo X-ray Dark-Field Chest Radiography of a Pig.

Gromann Lukas B LB De Marco Fabio F Willer Konstantin K Noël Peter B PB Scherer Kai K Renger Bernhard B Gleich Bernhard B Achterhold Klaus K Fingerle Alexander A AA Muenzel Daniela D Auweter Sigrid S Hellbach Katharina K Reiser Maximilian M Baehr Andrea A Dmochewitz Michaela M Schroeter Tobias J TJ Koch Frieder J FJ Meyer Pascal P Kunka Danays D Mohr Juergen J Yaroshenko Andre A Maack Hanns-Ingo HI Pralow Thomas T van der Heijden Hendrik H Proksa Roland R Koehler Thomas T Wieberneit Nataly N Rindt Karsten K Rummeny Ernst J EJ Pfeiffer Franz F Herzen Julia J

Scientific reports 20170706 1

X-ray chest radiography is an inexpensive and broadly available tool for initial assessment of the lung in clinical routine, but typically lacks diagnostic sensitivity for detection of pulmonary diseases in their early stages. Recent X-ray dark-field (XDF) imaging studies on mice have shown significant improvements in imaging-based lung diagnostics. Especially in the case of early diagnosis of chronic obstructive pulmonary disease (COPD), XDF imaging clearly outperforms conventional radiography. ...[more]

PMID: 28684858

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Project description:ObjectiveAssessing the advantage of x-ray dark-field contrast over x-ray transmission contrast in radiography for the detection of developing radiation-induced lung damage in mice.MethodsTwo groups of female C57BL/6 mice (irradiated and control) were imaged obtaining both contrasts monthly for 28 weeks post irradiation. Six mice received 20 Gy of irradiation to the entire right lung sparing the left lung. The control group of six mice was not irradiated. A total of 88 radiographs of both contrasts were evaluated for both groups based on average values for two regions of interest, covering (irradiated) right lung and healthy left lung. The ratio of these average values, R, was distinguished between healthy and damaged lungs for both contrasts. The time-point when deviations of R from healthy lung exceeded 3σ was determined and compared among contrasts. The Wilcoxon-Mann-Whitney test was used to test against the null hypothesis that there is no difference between both groups. A selection of 32 radiographs was assessed by radiologists. Sensitivity and specificity were determined in order to compare the diagnostic potential of both contrasts. Inter-reader and intra-reader accuracy were rated with Cohen's kappa.ResultsRadiation-induced morphological changes of lung tissue caused deviations from the control group that were measured on average 10 weeks earlier with x-ray dark-field contrast than with x-ray transmission contrast. Sensitivity, specificity, and accuracy doubled using dark-field radiography.ConclusionX-ray dark-field radiography detects morphological changes of lung tissue associated with radiation-induced damage earlier than transmission radiography in a pre-clinical mouse model.Key points• Significant deviations from healthy lung due to irradiation were measured after 16 weeks with x-ray dark-field radiography (p = 0.004). • Significant deviations occur on average 10 weeks earlier for x-ray dark-field radiography in comparison to x-ray transmission radiography. • Sensitivity and specificity doubled when using x-ray dark-field radiography instead of x-ray transmission radiography.

Dataset Information

In-vivo X-ray Dark-Field Chest Radiography of a Pig.

Publications

In-vivo X-ray Dark-Field Chest Radiography of a Pig.

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