Dataset Information

Depiction of pneumothoraces in a large animal model using x-ray dark-field radiography.

ABSTRACT: The aim of this study was to assess the diagnostic value of x-ray dark-field radiography to detect pneumothoraces in a pig model. Eight pigs were imaged with an experimental grating-based large-animal dark-field scanner before and after induction of a unilateral pneumothorax. Image contrast-to-noise ratios between lung tissue and the air-filled pleural cavity were quantified for transmission and dark-field radiograms. The projected area in the object plane of the inflated lung was measured in dark-field images to quantify the collapse of lung parenchyma due to a pneumothorax. Means and standard deviations for lung sizes and signal intensities from dark-field and transmission images were tested for statistical significance using Student's two-tailed t-test for paired samples. The contrast-to-noise ratio between the air-filled pleural space of lateral pneumothoraces and lung tissue was significantly higher in the dark-field (3.65?±?0.9) than in the transmission images (1.13?±?1.1; p?=?0.002). In case of dorsally located pneumothoraces, a significant decrease (-20.5%; p?>?0.0001) in the projected area of inflated lung parenchyma was found after a pneumothorax was induced. Therefore, the detection of pneumothoraces in x-ray dark-field radiography was facilitated compared to transmission imaging in a large animal model.

SUBMITTER: Hellbach K

PROVIDER: S-EPMC5805747 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature

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Depiction of pneumothoraces in a large animal model using x-ray dark-field radiography.

Hellbach Katharina K Baehr Andrea A De Marco Fabio F Willer Konstantin K Gromann Lukas B LB Herzen Julia J Dmochewitz Michaela M Auweter Sigrid S Fingerle Alexander A AA Noël Peter B PB Rummeny Ernst J EJ Yaroshenko Andre A Maack Hanns-Ingo HI Pralow Thomas T van der Heijden Hendrik H Wieberneit Nataly N Proksa Roland R Koehler Thomas T Rindt Karsten K Schroeter Tobias J TJ Mohr Juergen J Bamberg Fabian F Ertl-Wagner Birgit B Pfeiffer Franz F Reiser Maximilian F MF

Scientific reports 20180208 1

The aim of this study was to assess the diagnostic value of x-ray dark-field radiography to detect pneumothoraces in a pig model. Eight pigs were imaged with an experimental grating-based large-animal dark-field scanner before and after induction of a unilateral pneumothorax. Image contrast-to-noise ratios between lung tissue and the air-filled pleural cavity were quantified for transmission and dark-field radiograms. The projected area in the object plane of the inflated lung was measured in da ...[more]

PMID: 29422512

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Project description:ObjectiveAssessing the advantage of x-ray dark-field contrast over x-ray transmission contrast in radiography for the detection of developing radiation-induced lung damage in mice.MethodsTwo groups of female C57BL/6 mice (irradiated and control) were imaged obtaining both contrasts monthly for 28 weeks post irradiation. Six mice received 20 Gy of irradiation to the entire right lung sparing the left lung. The control group of six mice was not irradiated. A total of 88 radiographs of both contrasts were evaluated for both groups based on average values for two regions of interest, covering (irradiated) right lung and healthy left lung. The ratio of these average values, R, was distinguished between healthy and damaged lungs for both contrasts. The time-point when deviations of R from healthy lung exceeded 3σ was determined and compared among contrasts. The Wilcoxon-Mann-Whitney test was used to test against the null hypothesis that there is no difference between both groups. A selection of 32 radiographs was assessed by radiologists. Sensitivity and specificity were determined in order to compare the diagnostic potential of both contrasts. Inter-reader and intra-reader accuracy were rated with Cohen's kappa.ResultsRadiation-induced morphological changes of lung tissue caused deviations from the control group that were measured on average 10 weeks earlier with x-ray dark-field contrast than with x-ray transmission contrast. Sensitivity, specificity, and accuracy doubled using dark-field radiography.ConclusionX-ray dark-field radiography detects morphological changes of lung tissue associated with radiation-induced damage earlier than transmission radiography in a pre-clinical mouse model.Key points• Significant deviations from healthy lung due to irradiation were measured after 16 weeks with x-ray dark-field radiography (p = 0.004). • Significant deviations occur on average 10 weeks earlier for x-ray dark-field radiography in comparison to x-ray transmission radiography. • Sensitivity and specificity doubled when using x-ray dark-field radiography instead of x-ray transmission radiography.

Dataset Information

Depiction of pneumothoraces in a large animal model using x-ray dark-field radiography.

Publications

Depiction of pneumothoraces in a large animal model using x-ray dark-field radiography.

Similar Datasets

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