Ontology highlight
ABSTRACT:
SUBMITTER: Maione AG
PROVIDER: S-EPMC5500637 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 20160608 4
Current chronic wound treatments often fail to promote healing of diabetic foot ulcers (DFU), leading to amputation and increased patient morbidity. A critical mediator of proper wound healing is the production, assembly, and remodeling of the extracellular matrix (ECM) by fibroblasts. However, little is known about how these processes are altered in fibroblasts within the DFU microenvironment. Thus, we investigated the capacity of multiple, primary DFU-derived fibroblast strains to express, pro ...[more]