Group-Level Progressive Alterations in Brain Connectivity Patterns Revealed by Diffusion-Tensor Brain Networks across Severity Stages in Alzheimer's Disease.

ABSTRACT: Alzheimer's disease (AD) is a chronically progressive neurodegenerative disease highly correlated to aging. Whether AD originates by targeting a localized brain area and propagates to the rest of the brain across disease-severity progression is a question with an unknown answer. Here, we aim to provide an answer to this question at the group-level by looking at differences in diffusion-tensor brain networks. In particular, making use of data from Alzheimer's Disease Neuroimaging Initiative (ADNI), four different groups were defined (all of them matched by age, sex and education level): G₁ (N₁ = 36, healthy control subjects, Control), G₂ (N₂ = 36, early mild cognitive impairment, EMCI), G₃ (N₃ = 36, late

SUBMITTER: Rasero J 

PROVIDER: S-EPMC5500648 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature