Ontology highlight
ABSTRACT:
SUBMITTER: Knowles DA
PROVIDER: S-EPMC5501199 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Nature methods 20170522 7
Identifying interactions between genetics and the environment (GxE) remains challenging. We have developed EAGLE, a hierarchical Bayesian model for identifying GxE interactions based on associations between environmental variables and allele-specific expression. Combining whole-blood RNA-seq with extensive environmental annotations collected from 922 human individuals, we identified 35 GxE interactions, compared with only four using standard GxE interaction testing. EAGLE provides new opportunit ...[more]