Ontology highlight
ABSTRACT:
SUBMITTER: Taylor DL
PROVIDER: S-EPMC5901994 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Taylor D Leland DL Knowles David A DA Scott Laura J LJ Ramirez Andrea H AH Casale Francesco Paolo FP Wolford Brooke N BN Guan Li L Varshney Arushi A Albanus Ricardo D'Oliveira RD Parker Stephen C J SCJ Narisu Narisu N Chines Peter S PS Erdos Michael R MR Welch Ryan P RP Kinnunen Leena L Saramies Jouko J Sundvall Jouko J Lakka Timo A TA Laakso Markku M Tuomilehto Jaakko J Koistinen Heikki A HA Stegle Oliver O Boehnke Michael M Birney Ewan E Collins Francis S FS
PloS one 20180416 4
From whole organisms to individual cells, responses to environmental conditions are influenced by genetic makeup, where the effect of genetic variation on a trait depends on the environmental context. RNA-sequencing quantifies gene expression as a molecular trait, and is capable of capturing both genetic and environmental effects. In this study, we explore opportunities of using allele-specific expression (ASE) to discover cis-acting genotype-environment interactions (GxE)-genetic effects on gen ...[more]