Ontology highlight
ABSTRACT:
SUBMITTER: Sommese L
PROVIDER: S-EPMC5501211 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Sommese Linda L Zullo Alberto A Mancini Francesco Paolo FP Fabbricini Rossella R Soricelli Andrea A Napoli Claudio C
Epigenetics 20170106 6
Epigenetics is involved in the altered expression of gene networks that underlie insulin resistance and insufficiency. Major genes controlling β-cell differentiation and function, such as PAX4, PDX1, and GLP1 receptor, are epigenetically controlled. Epigenetics can cause insulin resistance through immunomediated pro-inflammatory actions related to several factors, such as NF-kB, osteopontin, and Toll-like receptors. Hereafter, we provide a critical and comprehensive summary on this topic with a ...[more]